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Accumulation of Indium-111-Labeled Granulocytes in Malignant Tumors

Department of Nuclear Medicine, Department of Geriatric Medicine, and Institute of Pathological Anatomy, Odense University Hospital, Odense, Denmark

Correspondence: For reprints contact: Kai G. Schmidt, MD, PhD, Dept. of Nuclear Medicine, Odense University Hospital, DK-5000 Odense C, Denmark.

ABSTRACT

In a retrospective study of 220 [¹¹¹In]granulocyte scintigrams from 208 patients, 25 patients had malignant neoplasms. Among these, tumor uptake of ¹¹¹In activity was observed in ten patients (intense activity in two patients with non-Hodgkin's lymphoma and colonic carcinoma, respectively; moderate uptake in a patient with non-Hodgkin's lymphoma, and in a patient with an ovarian carcinoma; weak activity in three patients with cerebral neoplasms; and activity within otherwise "cold" metastatic lesions of the liver in three patients). Microscopic investigation following specific granulocyte staining revealed the greatest extent of granulocyte infiltration in the tumors which took up ¹¹¹In activity, emphasizing the importance of tumor granulocyte infiltration as the single most important factor underlying tumor accumulation of ¹¹¹In activity during [¹¹¹In]granulocyte scintigraphy.

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