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Technetium-99m MAG₃, a Comparison with Iodine-123 and Iodine-131 Orthoiodohippurate, in Patients with Renal Disorders

Department of Nuclear Medicine, St. Bartholomew's Hospital, London, United Kingdom

Correspondence: For reprints contact: K. E. Britton, MD, Dept. of Nuclear Medicine, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE UK.

ABSTRACT

A Phase I study in 12 patients with renal disorders compared the simultaneous clearances of ^99mTc-labeled mercaptoacetyltriglycine (MAG₃) and ¹³¹I-labeled orthoiodohippurate (OIH). The ratio of MAG₃ to OIH clearance was 0.61 ± 0.08 as a result of its smaller volume of distribution, ratio 0.65 ± 0.09, for the clearance half-lives were similar, ratio 1.09 ± 0.12.A Phase II study performed serially in 20 patients with equal doses of [^99mTc]MAG₃ and [¹²³I]OIH gave images of equal quality. The relative renal functions were highly correlated (r = 0.97, p < 0.001) and transit time analyses gave good correlations: parenchymal transit time index r = 0.81, p < 0.05. We conclude that [^99mTc]MAG₃ has some advantages over [^99mTc]DTPA and is a suitable replacement for [¹²³I]hippuran in routine renal imaging, relative function, and transit time studies, but not for the accurate estimation of the renal plasma flow.

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