HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Thorstad, B. L. Articles by Luke, R. G. Search for Related Content PubMed PubMed Citation Articles by Thorstad, B. L. Articles by Luke, R. G.

Abnormal Captopril Renogram with a Technetium-99m-Labeled Hippuran Analog

Division of Nuclear Medicine, Department of Radiology, Division of Nephrology, University of Alabama Hospital, and Birmingham V. A. Medical Center, Birmingham, Alabama

Correspondence: For reprints contact: Charles D. Russell, MD, PhD, Div. of Nuclear Medicine, University of Alabama Hospital, 619—19th Street South, Birmingham, AL 35233.

ABSTRACT

A case of renovascular hypertension is presented in which the [¹³¹I]hippuran renogram was initially normal, but became strikingly abnormal upon administration of the angiotensin converting enzyme (ACE) inhibitor captopril. The patient presented with fibromuscular dysplasia of the renal arteries, which was shown by hippuran renography to be functionally significant on the right side. She became normotensive after angioplasty of the right renal artery. Hypertension recurred a year later, at which time the renogram was normal without captopril, but showed functionally significant left renal artery stenosis with captopril challenge. Both the conventional agent, [¹³¹I] hippuran, and an expetimental new 99^mTc-labaled hippuran analog, [^99mTc]MAG₃, were used. Angiography confirmed progression of disease on the left side, which was successfully treated by angioplasty. Functionally significant unilateral renal artery stenosis was thus demonstrated first on the right side and then, 1 yr later, on the left side, using hippuran and[^99mTc]MAG₃. Anatomic progression of disease was documented by angiography.