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Experimental Increase in Brain HIPDM Uptake by Hypercapnia

Division of Nuclear Medicine, Department of Radiology and Department of Oncology, University of Miami School of Medicine, Miami, Florida
Department of Nuclear Medicine, State University of New York at Buffalo, Buffalo, New York
Department of Medical Physics, University of Thessaloniki, Greece

Correspondence: For reprints contact: G. N. Sfakianakis, MD, University of Miami School of Medicine, Div. of Nuclear Medicine (D-57), P.O. Box 016960, Miami, FL 33101.

ABSTRACT

The 30-min brain uptake of [¹²⁵I] HIPDM was measured in conscious rat—normocapnic (n = 8), hypercapnic (n= 12), and hyperoxic (n= 6). A mean 41.2% higher uptake was found in the brains of hypercapnic animals (p < 0.01). In the three groups of rats, brain HIPDM uptake had a negative correlation with body weight (p < 0.001) and a positive correlation with arterial pCO₂ (p < 0.01), when adjusted for body weight. These results indicate that HIPDM uptake with hypercapnia may be used as a provocative test to measure cerebral blood flow reserves.