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Quantitative Measurement of Renal Perfusion Following Transplant Surgery

Division of Nuclear Medicine, University of Colorado Health Sciences Center, Denver, Colorado

Correspondence: For reprints contact: James L. Lear, MD, Nuclear Medicine (A034), University of Colorado Health Sciences Center, 4200 E. 9th Ave., Denver, CO 80262.

ABSTRACT

We developed an easily implemented clinical procedure for quantitative perfusion measurements in transplanted kidneys using intravenously administered [^99mTc]DTPA and the tracer fractionation technique. F = A(T) / _o^T [A_a(t)/V_a] dt, where F = renal blood flow, A(T) = DTPA activity in kidney at time = T, V_a = ultrasonographically measured femoral artery segment volume, T = time postinjection of F determination, and A_a(t) = time course of DTPA activity in femoral artery segment. The technique was applied to a group of 80 studies in 35 patients in whom an independent clinical determination of transplant function was available. Blood flow (units of ml/min) measured 439 ± 83 in normally functioning transplants, 248 ± 63 in transplants with acute tubular necrosis, 128 ± 62 in transplants with rejection, and 284 ± 97 in transplants with cyclosporine toxicity. These preliminary results indicate potential usefulness of this method in the evaluation of renal function following transplant surgery.