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In Vivo Measurement of Carbon-11 Thymidine Uptake in Non-Hodgkin's Lymphoma Using Positron Emission Tomography

Department of Hematology, University of Louvain, Medical School, Brussels
Positron Emission Tomography Laboratory, University of Louvain, Louvain-la-Neuve, Belgium

Correspondence: For reprints contact: A. Ferrant, MD, Cliniques Universitaires St-Luc, 10, Avenue Hippocrate, B-1200 Brussels, Belgium.

ABSTRACT

Carbon-11 thymidine (TdR) uptake using positron emission tomography (PET) has been measured in ten patients with non-Hodgkin's lymphoma (NHL). The rate of TdR uptake (mean ± s.d.) was of 0.009 ± 0.006 µmol. 100 cc^–1. min ^–1 in low-grade NHL. This rate was 0.063 ± 0.049 µmol. 100 cc^–1. min^–1 in intermediate-grade NHL and 0.159 µmol. 100 cc^–1. min^–1 in a patient with high-grade NHL. Lymphoma radioactivity reached a plateau at 0.42 ± 0.22 %. 100 cc^–1 of the injected dose from 10 min after injection. The highest ¹¹C uptakes were observed in the kidneys and in the liver (3.30 ± 1.30 and 2.10 ± 0.05 %. 100 cc^–1 of the injected dose, respectively). The lymphoma-to-muscle ratio was of 11.8 ± 1.7, whereas the lymphoma-to-intestine ratio was of 1.5 ± 0.7. Accordingly, the measurement of [¹¹C]TdR uptake in the abdomen may need other imaging methods for adequate interpretation. The results suggest that [¹¹C]TdR uptake using PET might be a method for noninvasively measuring cell proliferation in vivo.

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