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Pentavalent [^99mTc]DMSA, [¹³¹I]MIBG, and [^99mTc]MDP-An Evaluation of Three Imaging Techniques in Patients with Medullary Carcinoma of the Thyroid

Department of Nuclear Medicine, Guy's Hospital, London
Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, England

Correspondence: For reprints contact: Susan E.M. Clarke, MD, Dept. of Nuclear Medicine, Guy's Hospital, St Thomas St., London, SE1 9RT.

ABSTRACT

Nine patients with histologically proven medullary carcinoma of the thyroid (MCT) were imaged using pentavalent [^99mTc]dimercaptosuccinic acid [(V)DMSA], [¹³¹I] metaiodobenzylguanidine (MIBG) and [^99mTc]methylene diphosphonate (MDP). Technetium-99m (V)DMSA demonstrated most of the tumor sites in eight patients with proven metastases, with an overall sensitivity of 95% in lesion detection. Iodine-131 MIBG showed definite uptake in some of the tumor sites in three of the nine patients imaged, with equivocal uptake seen in a further one patient, with sensitivity of only 11% for lesion detection. Technetium-99m MDP demonstrated bony metastases only, in four of the patients imaged yielding a sensitivity of 61%. Technetium-99m (V)DMSA has been demonstrated in this study to be a useful imaging agent in patients with MCT, showing uptake in significantly more lesions and with better imaging qualities than [¹³¹I]MIBG, and with the ability to detect soft tissue as well as bony metastases.

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