HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) A correction has been published Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Deutsch, E. Articles by Hirth, W. Search for Related Content PubMed PubMed Citation Articles by Deutsch, E. Articles by Hirth, W.

In Vivo Inorganic Chemistry of Technetium Cations

Biomedical Chemistry Research Center, Department of Chemistry, University of Cincinnati, Cincinnati, Ohio

Correspondence: For reprints contact: Edward Deutsch, Biomedical Chemistry Research Center, Dept. of Chemistry, University of Cincinnati, Cincinnati, OH 45221.

ABSTRACT

Technetium-99m cations are of interest because of their potential use as myocardial perfusion imaging agents. These species can undergo in vivo reactions which markedly affect their biodistribution patterns. Four such cases of reactions are presented and discussed: (1) simple ligand substitution; (2) metal centered redox processes; (3) reactions of coordinated ligands; (4) outer sphere association reactions. New experimental techniques appropriate for investigating these reactions at the 10^–10M concentration level of technetium encountered in vivo are also presented and discussed. The latter three classes of reactions are illustrated by examples taken from the recent literature and from unpublished data.

FOOTNOTES

Presented as part of the Categorical Seminar "The Chemistry of Radiopharmaceuticals In Vivo: Methods and State of Characterization" at the 33rd annual meeting of the Society of Nuclear Medicine, June 21, 1986, Washington, DC.