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The Journal of Nuclear Medicine Vol. 28 No. 9 1484-1487
© 1987 by Society of Nuclear Medicine
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Iodine-123 HIPDM Brain Imaging Findings in Subacute Spongiform Encephalopathy (Creutzfeldt-Jakob Disease)

W.J. Shih, W.R. Markesbery, D.B. Clark, S. Goldstein, P.A. Domstad, J.J. Coupal, H. Kung, S.T. DeKosky and F.H. DeLand*

Nuclear Medicine Service, Neurology Service and Radiology Service, Veterans Administration and University of Kentucky Medical Centers, Lexington, Kentucky
Department of Nuclear Medicine, University of Buffalo, Buffalo, New York

Correspondence: For reprints contact: W.J. Shih, MD, Nuclear Medicine Service, Veterans Administration and University of Kentucky Medical Centers, Lexington, KY 40511.

ABSTRACT

Decreased perfusion of the left frontal and left temporoparietal cortex has been shown in [123I] HIPDM planar and single photon emission computed tomographic images of a patient with Creutzfeldt-Jakob disease (CJD) that was proven by brain biopsy and subsequent autopsy. An EEG showed diffuse, periodic discharges most prominent to the left hemisphere. Concurrent head computed tomography (CT), nuclear magnetic resonance (NMR), and cerebral angiographic studies were negative. Abnormalities demonstrated by [123I]HIPDM imaging and by EEG may represent changes in neurophysiological and neurochemical status while cerebral angiography, CT, and possibly NMR register only anatomic or structural lesions. Premortem diagnosis of CJD depends on brain biopsy; the availability of the [123I] HIPDM study may provide regional cerebral neurochemical and neurophysiological information, guiding or avoiding brain biopsy in the appropriate clinical setting.

FOOTNOTES

* Present address: VA Medical Center, Syracuse, NY.






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Copyright © 1987 by the Society of Nuclear Medicine.