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Comparison of Gallium-67 Versus Indium-111 Monoclonal Antibody (96.5, ZME-018) in Detection of Human Melanoma in Athymic Mice

Departments of Diagnostic Radiology, Oncology and Pathology, Yale University School of Medicine, New Haven, Connecticut

Correspondence: For reprints contact: Paul Hoffer, MD, Dept. of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510.

ABSTRACT

We compared the biodistribution of two radiolabeled, whole, tumor selective monoclonal antibodies ([¹¹¹In]96.5, [¹¹¹In]ZME-018) to ⁶⁷Ga in nude mice bearing a human melanoma known to express p97 antigen. Localization of gallium was determined 48 hr following i.v. injection. Localization of the radiolabeled antibodies was determined at 3 days and 7 days following i.v. injection. All agents showed more or less similar absolute tumor uptake which varied between 22% and 36% of the injected dose per gram of tumor. Only the tumor uptake of [¹¹¹In] 96.5 antibody at 7 days was significantly lower than the ⁶⁷Ga uptake at 48 hr. However, uptake in normal tissues was generally higher for both antibodies at 3 and 7 days than for ⁶⁷Ga uptake at 48 hr. Therefore, the tumor-to-blood ratio for ⁶⁷Ga was tenfold higher than that for either antibody, the tumor-to-muscle ratio was twofold higher. Bone was the only organ in which the tumor-to-organ ratio was consistently higher with radiolabeled antibody than with ⁶⁷Ga. The tumor-to-liver and tumor-to-intestine ratios were comparable. Localization of the two tumor selective antibodies was greater than a nonspecific "control antibody" ([¹¹¹In]CEA) and change in specific activity from 0.17 mCi/mg to 3.3 mCi/mg did not influence localization. From these animal data it may be anticipated that tumor imaging with [¹¹¹In]96.5 or [¹¹¹In]ZME-018 will not be superior to imaging with ⁶⁷Ga for detection of melanoma.