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Characterization of In Vivo Chemistry of Cations in the Heart

E.I. Du Pont de Nemours and Co., Inc., Medical Products Department, Diagnostic Imaging Research and Immunopharmaceutical R&D, North Billerica, Massachusetts

Correspondence: For reprints contact: S.A. Mousa, E.I. DuPont de Nemours and Co., Inc., Medical Products Dept, Diagnostic Imaging Research, 331 Treble Cove Rd., No. Billerica, MA 01862.

ABSTRACT

A variety of laboratory procedures can be used to define the chemistry and pharmacokinetics of myocardial cationic imaging agents. These methods are utilized to define the in vivo chemistry of cationic heart agents, in order to understand the kinetics and mechanisms of: (a) tissue and cellular transport, (b) subcellular distribution, and (c) intracellular localization. Transport across cell membranes can be active, passive or facilitated. Studies performed in erythrocytes, heart cells, slices and isolated perfused hearts using methods for separation of metabolites have shown a high degree of myocardial specificity for [^99mTc]hexakis alkyl isonitrile by an uptake mechanism different from ²⁰¹Tl. These studies demonstrate the importance of in vivo chemistry and pharmacokinetics in the development of new radiopharmaceuticals.