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Preleukemia Following Large Dose Radioiodide Therapy for Metastatic Thyroid Carcinoma

Departments of Medicine & Radiology, Saint Francis Hospital and Medical Center, Hartford
Department of Nuclear Medicine, University of Connecticut Health Center, Farmington, Connecticut

Correspondence: For reprints contact: Richard P. Spencer, MD, Dept. of Nuclear Medicine, University of Connecticut Health Center, Farmington, CT 06032.

ABSTRACT

A 67-yr-old woman had follicular thyroid carcinoma metastatic to several osseous sites. There was also evidence of functioning pulmonary metastases. She was treated by total thyroidectomy and multiple closes of radioiodicle (¹³¹I). Approximately 2.5 yr after the initial ablative dose, and a total dose of 820 mCi of sodium iodide ¹³¹I, preleukemic changes were noted in the bone marrow. This appears to be the second case of preleukemia that bears a temporal relationship to radioiodicle therapy of thyroid carcinoma, and the first in which radioiodide alone has been used in therapy (without additional external radiation).

This article has been cited by other articles:

				D. Focosi, S. Galimberti, and M. Petrini Acute myeloid leukemia and follicular lymphoma after very low dose radioiodine therapy for thyroid diseases Haematologica, September 1, 2007; 92(9): e96 - e97. [Full Text] [PDF]