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Suppression by Perchlorate of Technetium-99m and Iodine-123 Secretion in Milk of Lactating Goats

Department of Nuclear Medicine, Kent and Canterbury Hospital, Canterbury, Kent
Agricultural and Food Research Council, Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, United Kingdom

Correspondence: For reprints contact: P.J. Mountford, PhD, Dept. of Nuclear Medicine, Kent and Canterbury Hospital, Canterbury, Kent CT1 3NG, U.K.

ABSTRACT

Lactating goats were infused with either technetium-99m (^99mTc) or iodine-123 (¹²³I) together with chlorine-36 (³⁶Cl) through an indwelling catheter previously placed in an external pudic mammary artery. The radioisotope infusions were repeated together with 100 mg of sodium perchlorate. There was a rapid transfer of ^99mTc and ¹²³I into milk, reaching a peak concentration 30 min after a 15-min infusion. The fractional secretion of ^99mTc and ¹²³I in milk was reduced by 70%–80% and 60%–66%, respectively, by perchlorate. The fractional secretion of 36Cl was not affected by perchlorate, and the shape of the ³⁶Cl secretion curve differed from those of 99mTc and ¹²³I, which were similar. It is probable, therefore, that the latter nuclides were secreted by a transport route different from that of chloride. Available data describing the secretion of ^99mTc in human milk after pertechnetate administration was reviewed, and it was concluded that perchlorate pretreatment significantly reduced the secretion of ^99mTc in human breast milk.

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