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Gated Blood-Pool Imaging in Mechanical Left Ventricular Assistance Following Myocardial Infarction in Dogs

Department of Cardiac Surgery, Royal Infirmary, Glasgow, Scotland

Correspondence: For reprints contact: William Martin, MD, Dept. of Cardiac Surgery, Royal Infirmary, Alexandra Parade, Glasgow G31 2ER, Scotland.

ABSTRACT

Gated blood-pool scanning has been used to assess the physiological effects of left ventricular assistance following acute myocardial infarction in dogs. Both left atrial-aortic and left ventricular-aortic bypass improve survival up to 6 hr after acute coronary occlusion, compared with control animals. The initial measurement of left ventricular ejection fraction (LVEF) following occlusion appears predictive of the need for ventricular assistance. Assisted animals maintain their level of left ventricular function until 6 hr in contrast with control animals, whose function steadily deteriorates over this period. There was no demonstrable recovery in regional ventricular function in the infarcted territory over this period, and in all assisted animals the right ventricular function deteriorated more rapidly than in controls. These results demonstrate the efficacy of left ventricular assistance in terms of improved survival and preserved left ventricular function. Gated blood-pool ventricutography has also been shown to be a suitable technique for monitoring the physiological changes during left ventricular assistance.