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Myocardial Uptake of Thallium and Rubidium During Alterations in Perfusion and Oxygenation in Isolated Rabbit Hearts

Department of Nuclear Medicine and Cardiology, University of Massachusetts Medical Center, Worcester, Massachusetts

Correspondence: For reprints contact: Jeffrey A. Leppo, MD, Dept. of Nuclear Medicine, University of Massachusetts Medical Center, 55 Lake Ave. North, Worcester, MA 01605.

ABSTRACT

The comparative effects of altered cellular function and coronary perfusion on myocardial ²⁰¹Tl and ⁸³Rb uptake were evaluated in three groups of isolated rabbit hearts having isovolumic contractions. Paired-indication dilution experiments were performed with ²⁰¹Tl, ⁸³Rb, and ¹¹¹In-labeled albumin as an intravascular reference marker. In Group A hearts (n = 12), isotope transport was determined during control, hypoxia, and ischemia. In Group B hearts (n = 8), isotope transport was measured at control flow and again at a 50% and 80% reduction. In Group C hearts (n = 8) only ²⁰¹Tl uptake was determined at control and following coronary reperfusion. Myocardial ²⁰¹Tl and ⁸³Rb transport were not significantly different and were proportional to flow. Although all interventions caused significant hemodynamic alterations, neither tracer was affected by hypoxia at constant flow. Thallium-201 permeation, however, was transiently decreased immediately after coronary reperfusion. We conclude that myocardial uptake of ²⁰¹Tl and ⁸³Rb are similar and directly related to flow, but do not reflect hypoxia induced cellular dysfunction.

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