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The Journal of Nuclear Medicine Vol. 28 No. 3 378-382
© 1987 by Society of Nuclear Medicine
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Chemical Breakdown of Technetium-99m DTPA During Nebulization

D. L. Waldman, D. A. Weber, G. Oberdörster, S. R. Drago, M. J. Utell, R. W. Hyde and P. E. Morrow

Departments of Chemistry, Radiology, Radiation Biology and Biophysics, and Medicine, University of Rochester, Rochester, New York

Correspondence: For reprints contact: David L. Waldman, Dept of Nuclear Medicine, Box 620, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642.

ABSTRACT

Aerosols of 99mTc diethylenetriaminepentaacetic acid ([99mTc]DTPA) used for measuring lung permeability and lung ventilation require a radioaerosol delivery system to produce an aerosol with reproducible size and radiochemical purity. To test how well nebulizers meet this requirement, radiochemical purity of aerosols produced with a jet and an ultrasonic nebulizer was evaluated. The activity median aerodynamic diameter (AMAD) and geometric standard deviation ({sigma}g) of radioaerosols were 0.46 µm ({sigma}g = 1.6) for the jet nebulizer and 0.70 µm ({sigma}g = 1.7) for the ultrasonic nebulizer. Paper and liquid chromatographic assays were obtained on the [99mTc]DTPA aerosol solute produced with each nebulizer. The results of these tests showed major differences in radiochemical purity. Aerosols produced in the jet nebulizer consistently showed greater than 90% of the radioactivity bound to the DTPA ligand whereas aerosols produced in the ultrasonic nebulizer showed <10% of the radioactivity bound to DTPA. The results support the need to test radiochemical purity of aerosols before using an aerosol nebulizer for pulmonary imaging and clearance studies.






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Copyright © 1987 by the Society of Nuclear Medicine.