HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Boudreau, R. J. Articles by Loken, M. K. Search for Related Content PubMed PubMed Citation Articles by Boudreau, R. J. Articles by Loken, M. K.

Comparison of the Biodistribution of Manganese-54 DTPA and Gadolinium-153 DTPA in Dogs

Division of Nuclear Medicine, Department of Radiology, University of Minnesota Hospitals, Minneapolis, Minnesota

Correspondence: For reprints contact: R. Boudreau, MD, PhD, Box 382 Mayo, University of Minnesota Hospitals, 420 Delaware St. S.E., Minneapolis, MN 55455.

ABSTRACT

The biodistribution of [⁵⁴Mn]DTPA and [¹⁵³Gd]DTPA dimeglumine were investigated and compared following i.v. administration to fasting anesthetized dogs. Unlike most previously reported metal ion-DTPA complexes, [⁵⁴Mn]DTPA showed high uptakes in several organs including the liver, bile, pancreas, bowel, and kidney. This uptake was independent of the pH of the injected solution. Accumulation in these organs suggests a potential role for [Mn]DTPA as a paramagnetic contrast agent for NMR imaging. With the exception of the kidneys, [¹⁵³Gd]DTPA showed no evidence of tissue specific uptake over the course of 4 hr, consistent with it being an extracellular ion that is cleared by glomerular filtration.