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Effect of Bronchodilation on the Deposition and Clearance of Radioaerosol in Bronchial Asthma in Remission

Department of Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University, Sendai 980, Japan

Correspondence: For reprints contact: Toyoharu Isawa, MD, Dept. of Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University, 4-1 Seiryomachi, Sendai 980, Japan.

ABSTRACT

Radioaerosol inhalation lung cine-scintigraphy and lung function tests were performed on ten patients with bronchial asthma in remission before and after inhalation of salbutamol following intravenously administered aminophylline. Radioaerosol inhalation lung cine-scintigraphy was very useful in revealing the changes not only in the deposition patterns of inhaled aerosol in the lungs but also in the dynamic transport of mucus on the airways. The bronchodilating effect of the combined treatment was significant; the inhaled aerosol deposited more homogeneously and less centrally in the lungs, the "penetration index" and the alveolar deposition ratio (ALDR) increased from 31 ± 3 to 49 ± 7%, and from 29 ± 2% to 39 ± 1%, respectively, while the airway deposition ratio (ADR) decreased from 72 ± 2 to 61 ± 1% immediately after the treatment. Lung function data including FVC, FEV 1.0, FEV 1.0%, MMF, V50 and Vp significantly improved after the treatment. There was, however, little visual or quantitative improvement in mucociliary clearance after the treatment.

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