| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cattedra di Endocrinologia e Medicina Costituzionale, University of Pisa, USL 12, Pisa, Italy
Correspondence: For reprints contact: F. Pacini, MD, Cattedra di Endocrinologia, Universit`a di Pisa, Viale del Tirreno 64, 56018 Tirrenia (Pisa), Italy.
ABSTRACT
Serum thyroglobulin (Tg) measurements in patients with treated differentiated thyroid cancer are usually well correlated with the presence or absence of residual or metastatic thyroid tissue. However, it is not rare to find a patient with detectable serum Tg levels but negative 131I whole-body scan (WBS) and no evidence of disease activity. To clarify the reason for this discrepancy, we decided to perform the WBS after the administration of a therapeutic dose of 131I in 17 consecutive patients in whom serum Tg was detectable while the WBS performed with a 5 mCi tracer dose was negative (12.6% of 135 patients studied with both WBS and serum Tg). The result of this study demonstrated that after this procedure the WBS became positive for significant residual or metastatic areas of radioiodine uptake in all patients but one. Such data indicate that in our patients the presence of circulating Tg is not a false-positive Tg result, but is due to the presence of residual or metastatic tissue that is not detected in the conventional WBS, that can be visualized using therapeutic doses. Preliminary follow-up data indicate that this procedure may also have therapeutic effect, although the relevance of this aspect remains to be established.
This article has been cited by other articles:
|
|
 |
|
  R. T. Kloos Approach to the Patient with a Positive Serum Thyroglobulin and a Negative Radioiodine Scan after Initial Therapy for Differentiated Thyroid Cancer J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1519 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Zophel, G. Wunderlich, and J. Kotzerke A Highly Sensitive Thyroglobulin Assay Has Superior Diagnostic Sensitivity for Recurrence of Differentiated Thyroid Cancer in Patients Undergoing TSH Suppression J. Nucl. Med., March 1, 2006; 47(3): 552 - 553. [Full Text] [PDF]
|
|
|
|
|
|
C. Ma, A. Kuang, J. Xie, and T. Ma Possible Explanations for Patients with Discordant Findings of Serum Thyroglobulin and 131I Whole-Body Scanning J. Nucl. Med., September 1, 2005; 46(9): 1473 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Mazzaferri Empirically Treating High Serum Thyroglobulin Levels J. Nucl. Med., July 1, 2005; 46(7): 1079 - 1088. [Full Text] [PDF]
|
|
|
|
|
|
C. Ma, J. Xie, and A. Kuang Is Empiric 131I Therapy Justified for Patients with Positive Thyroglobulin and Negative 131I Whole-Body Scanning Results? J. Nucl. Med., July 1, 2005; 46(7): 1164 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Robbins and M. J. Schlumberger The Evolving Role of 131I for the Treatment of Differentiated Thyroid Carcinoma J. Nucl. Med., January 1, 2005; 46(1_suppl): 28S - 37S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Mazzaferri A Randomized Trial of Remnant Ablation--In Search of an Impossible Dream? J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3662 - 3664. [Full Text] [PDF]
|
|
|
|
|
|
M. Toubeau, C. Touzery, P. Arveux, G. Chaplain, G. Vaillant, A. Berriolo, J.-M. Riedinger, C. Boichot, A. Cochet, and F. Brunotte Predictive Value for Disease Progression of Serum Thyroglobulin Levels Measured in the Postoperative Period and After 131I Ablation Therapy in Patients with Differentiated Thyroid Cancer J. Nucl. Med., June 1, 2004; 45(6): 988 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Elisei, A. Vivaldi, L. Agate, E. Molinaro, C. Nencetti, L. Grasso, A. Pinchera, and F. Pacini Low Specificity of Blood Thyroglobulin Messenger Ribonucleic Acid Assay Prevents Its Use in the Follow-Up of Differentiated Thyroid Cancer Patients J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 33 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pacini, E. Molinaro, M. G. Castagna, L. Agate, R. Elisei, C. Ceccarelli, F. Lippi, D. Taddei, L. Grasso, and A. Pinchera Recombinant Human Thyrotropin-Stimulated Serum Thyroglobulin Combined with Neck Ultrasonography Has the Highest Sensitivity in Monitoring Differentiated Thyroid Carcinoma J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3668 - 3673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Mazzaferri, R. J. Robbins, C. A. Spencer, L. E. Braverman, F. Pacini, L. Wartofsky, B. R. Haugen, S. I. Sherman, D. S. Cooper, G. D. Braunstein, et al. A Consensus Report of the Role of Serum Thyroglobulin as a Monitoring Method for Low-Risk Patients with Papillary Thyroid Carcinoma J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1433 - 1441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Baudin, C. D. Cao, A. F. Cailleux, S. Leboulleux, J. P. Travagli, and M. Schlumberger Positive Predictive Value of Serum Thyroglobulin Levels, Measured during the First Year of Follow-Up after Thyroid Hormone Withdrawal, in Thyroid Cancer Patients J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1107 - 1111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Parthasarathy and E. S. Crawford Treatment of Thyroid Carcinoma: Emphasis on High-Dose 131I Outpatient Therapy J. Nucl. Med. Technol., December 1, 2002; 30(4): 165 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Santini, V. Bottici, R. Elisei, L. Montanelli, S. Mazzeo, F. Basolo, A. Pinchera, and F. Pacini Cytotoxic Effects of Carboplatinum and Epirubicin in the Setting of an Elevated Serum Thyrotropin for Advanced Poorly Differentiated Thyroid Cancer J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4160 - 4165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pacini, M. Capezzone, R. Elisei, C. Ceccarelli, D. Taddei, and A. Pinchera Diagnostic 131-Iodine Whole-Body Scan May Be Avoided in Thyroid Cancer Patients Who Have Undetectable Stimulated Serum Tg Levels After Initial Treatment J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1499 - 1501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Fatourechi, I. D. Hay, H. Javedan, G. A. Wiseman, B. P. Mullan, and C. A. Gorman Lack of Impact of Radioiodine Therapy in Tg-Positive, Diagnostic Whole-Body Scan-Negative Patients with Follicular Cell-Derived Thyroid Cancer J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1521 - 1526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Alzahrani, S. Bakheet, M. Al Mandil, A. Al-Hajjaj, A. Almahfouz, and A. Al Haj 123I Isotope as a Diagnostic Agent in the Follow-Up of Patients with Differentiated Thyroid Cancer: Comparison with Post 131I Therapy Whole Body Scanning J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5294 - 5300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pacini, L. Agate, R. Elisei, M. Capezzone, C. Ceccarelli, F. Lippi, E. Molinaro, and A. Pinchera Outcome of Differentiated Thyroid Cancer with Detectable Serum Tg and Negative Diagnostic 131I Whole Body Scan: Comparison of Patients Treated with High 131I Activities Versus Untreated Patients J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4092 - 4097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hooft, O. S. Hoekstra, W. Deville, P. Lips, G. J. J. Teule, M. Boers, and M. W. van Tulder Diagnostic Accuracy of 18F-Fluorodeoxyglucose Positron Emission Tomography in the Follow-Up of Papillary or Follicular Thyroid Cancer J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3779 - 3786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Mazzaferri and R. T. Kloos Current Approaches to Primary Therapy for Papillary and Follicular Thyroid Cancer J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1447 - 1463. [Full Text]
|
|
|
|
|
|
M T. Bajen, S. Mane, A. Munoz, and J. Ramon Garcia Effect of a Diagnostic Dose of 185 MBq 131I on Postsurgical Thyroid Remnants J. Nucl. Med., December 1, 2000; 41(12): 2038 - 2042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. van Tol, P. L. Jager, R. P. F. Dullaart, and T. P. Links Follow-Up in Patients with Differentiated Thyroid Carcinoma with Positive 18F-Fluoro-2-Deoxy- D-Glucose-Positron Emission Tomography Results, Elevated Thyroglobulin Levels, and Negative High-Dose 131I Posttreatment Whole Body Scans J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 2082a - 2083. [Full Text]
|
|
|
|
|
|
A. F. Cailleux, E. Baudin, J. P. Travagli, M. Ricard, and M. Schlumberger Is Diagnostic Iodine-131 Scanning Useful after Total Thyroid Ablation for Differentiated Thyroid Cancer? J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 175 - 178. [Abstract] [Full Text]
|
|
|
|
|
|
B. R. Haugen, F. Pacini, C. Reiners, M. Schlumberger, P. W. Ladenson, S. I. Sherman, D. S. Cooper, K. E. Graham, L. E. Braverman, M. C. Skarulis, et al. A Comparison of Recombinant Human Thyrotropin and Thyroid Hormone Withdrawal for the Detection of Thyroid Remnant or Cancer J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 3877 - 3885. [Abstract] [Full Text]
|
|
|
|
|
|
W. Wang, H. Macapinlac, S. M. Larson, S. D. J. Yeh, T. Akhurst, R. D. Finn, J. Rosai, and R. J. Robbins [18F]-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Localizes Residual Thyroid Cancer in Patients with Negative Diagnostic 131I Whole Body Scans and Elevated Serum Thyroglobulin Levels J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2291 - 2302. [Abstract] [Full Text]
|
|
|
|
|
|
M. Schlumberger Use of Radioactive Iodine in Patients with Papillary and Follicular Thyroid Cancer: Towards A Selective Approach J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4201 - 4203. [Full Text]
|
|
|
|
|
|
J. P. Travagli, A. F. Cailleux, M. Ricard, E. Baudin, B. Caillou, C. Parmentier, and M. Schlumberger Combination of Radioiodine (131I) and Probe-Guided Surgery for Persistent or Recurrent Thyroid Carcinoma J. Clin. Endocrinol. Metab., August 1, 1998; 83(8): 2675 - 2680. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. J. Schlumberger Papillary and Follicular Thyroid Carcinoma N. Engl. J. Med., January 29, 1998; 338(5): 297 - 306. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Calzolari, P.-Y. Marquet, B. Pau, C. A. Spencer, and M. Takeuchi Thyroglobulin IRMA Pasteur Immunoassay: Sensitivity of the Assay and Interference from Thyroglobulin Autoantibodies • The authors of the above-mentioned article and editorial reply: Clin. Chem., February 1, 1997; 43(2): 413 - 415. [Full Text]
|
|
|
|
|
|
A. Z. Rudavsky and L. M. Freeman Treatment of Scan-Negative, Thyroglobulin-Positive Metastatic Thyroid Cancer Using Radioiodine 131I and Recombinant Human Thyroid Stimulating Hormone J. Clin. Endocrinol. Metab., January 1, 1997; 82(1): 11 - 14. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
