HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Thomas, K. D. Articles by Williams, C. M. Search for Related Content PubMed PubMed Citation Articles by Thomas, K. D. Articles by Williams, C. M.

Radiation Dosimetry of Iodine-123 HEAT, an Alpha-1 Receptor Imaging Agent

Veterans Administration Medical Center and Department of Radiology, University of Florida, Gainesville, Florida

Correspondence: For reprints contact: Kathleen D. Thomas, Office of the Director (002A), Veterans Administration Medical Center, Gainesville, FL 32602.

ABSTRACT

Biologic distribution data in the rat were obtained for the alpha-1 adrenoceptor imaging agent (±)2-[ß-(iodo-4-hydroxyphenyl)ethylaminomethyl] tetralone (HEAT) labeled with [¹²⁵I].The major excretory routes were through the liver (67%) and the kidney (33%). Internal radiation absorbed dose estimates to nine source organs, total body, the GI tract, gonads, and red bone marrow were calculated for the human using the physical decay data for [¹²³I]. The critical organ was found to be the lower large intestine, receiving 1.1 rad per mCi of [¹²³I]HEAT administered. The total-body dose was found to be 58 mrad per mCi.