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Quantification of Left-Ventricular Regional Dyssynergy by Radionuclide Angiography

The University of Texas Health Science Center at San Antonio, Texas

Correspondence: For reprints contact: Mark R. Starling, MD, University of Michigan, Dept. of Internal Medicine/Cardiology Div., Veterans Administration Medical Center, 2215 Fuller Rd., Ann Arbor, MI 48105.

ABSTRACT

To determine whether variables obtained from Fourier analysis of gated equilibrium radionuclide angiographie (RNA) images can detect and quantify changes in left-ventricular (LV) regional wall motion induced by transient ischemia, 11 chronically instrumented dogs were simultaneously studied with hemodynamic measurements and RNA during control, left circumflex (LCx) coronary artery occlusion, and postocclusion conditions. The dogs were preinstrumented with aortic and LV catheters, electromagnetic aortic and LCx coronary artery flow probes, high-fidelity LV micromanometers, LCx coronary artery occluders, and 4-mm ultrasonic transverse LV diameter and 2-mm regional LV segment crystal pairs. Radionuclide LV regional phase and amplitude variables were calculated for each condition. The absolute changes in LCx region RNA mean, median, and standard deviation of mean phase correlated with the percent changes in LCx segment crystal fractional shortening (r = –0.71, –0.64, and –0.51, respectively; all p 0.01). Similarly, the absolute changes and percent changes in LCx region RNA mean amplitude per pixel correlated with the percent changes in LCx segment crystal fractional shortening (r = 0.89 and 0.94, respectively; both p<0.001). When these LCx region RNA phase variables were subgrouped according to mild or severe depression or augmentation in LCx segment crystal fractional shortening, progressive differences were observed between the average values for these subgroups (p<0.05 to p<0.001). These data, therefore, suggest that these regional RNA phase variables may be able to detect and quantify alterations in LV contraction patterns due to transient ischemia.

FOOTNOTES

Presented in part at the 34th Annual Scientific Sessions of the American College of Cardiology, Anaheim, CA, March 1985.

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