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The Journal of Nuclear Medicine Vol. 28 No. 10 1599-1603
© 1987 by Society of Nuclear Medicine
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Routine Synthesis of Carbon-11-Carboxyl-Labeled L-Dopa

Michael J. Adam, John R. Grierson, Thomas J. Ruth, Ken Pedersen and Brian D. Pate

UBC/TRIUMF Program on Positron Emission Tomography, University of British Columbia, Vancouver, Canada V6T 2A3

Correspondence: For reprints contact: Michael J. Adam, TRIUMF, 4004 Wesbrook Mall, Vancouver, B.C., Canada V6T 2A3.

ABSTRACT

Carbon-11-carboxyl-labeled L-dopa has been synthesized by the modified Bucherer-Strecker method. The reaction mixture was first purified by chiral HPLC followed by deprotection using hydriodic acid. The entire procedure was performed in a remotely operated system which gave the product in 28% radiochemical yield (decay corrected) in an overall synthesis time of 55–60 min.






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Copyright © 1987 by the Society of Nuclear Medicine.