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Fluorine-18-N-Methylspiroperidol: Radiolytic Decomposition as a Consequence of High Specific Activity and High Dose Levels

Chemistry Department, Brookhaven National Laboratory, Upton, NY

Correspondence: For reprints contact: Robert R. MacGregor, MD, Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973.

ABSTRACT

High specific activity [¹⁸F]N-methylspiroperidol(8-[4-(4-[¹⁸F]fluorophenyl)-4-oxobutyl]-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 5–10 mCi/ml, 4–8 Ci/µmol at EOB) in saline solution undergoes significant radiolytic decomposition resulting in a decrease in radiochemical purity of 10–25% during the first hour. The rate of decomposition is affected by the specific activity, total dose to and chemical composition of the solution. That radiolysis is responsible for the observed decomposition was verified by the observation that unlabeled N-methylspiroperidol is decomposed in the presence of [¹⁸F]fluoride.