HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Jagust, W. J. Articles by Knittel, B. L. Search for Related Content PubMed PubMed Citation Articles by Jagust, W. J. Articles by Knittel, B. L.

Methodologic Factors Affecting PET Measurements of Cerebral Glucose Metabolism

Department of Neurology, Veterans Administration Medical Center, Martinez
Department of Neurology, School of Medicine, University of California, Davis
Donner Laboratory, University of California, Berkeley, California

Correspondence: For reprints contact: William J. Jagust, MD, Dept. of Neurology (127), VA Medical Center, 150 Muir Rd., Martinez, CA 94553.

ABSTRACT

Measurements of cerebral glucose utilization rates in similar populations of human subjects under similar conditions vary considerably because of methods used in data collection and analysis. Using data acquired in two patients, we evaluated the effects of time schedule of data collection, region of interest size, method of attenuation correction, and input function shape on LCMR_glu determined by dynamic positron emission tomographic scanning and calculation of rate constants. These different strategies of data acquisition and analysis produced variations of 3 to 14% in calculated LCMR_glu. These factors, in conjunction with the well described effects of instrument resolution and sensitivity may account for data discrepancies in the literature.