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Early Diagnosis of Acute Postoperative Renal Transplant Rejection by Indium-111-Labeled Platelet Scintigraphy

Departments of Radiology, Renal Transplant Surgery, and Biostatistics, Froedtert Memorial Lutheran Hospital, Medical College of Wisconsin, Milwaukee, Wisconsin

Correspondence: For reprints contact: B. David Collier, MD, Milwaukee County Medical Complex, 8700 W. Wisconsin Ave., Milwaukee, WI 53226.

ABSTRACT

A prospective evaluation of ¹¹¹In-labeled platelet scintigraphy (IPS) for the early diagnosis of acute postoperative renal transplant rejection (TA) was undertaken. The results of IPS were compared with in vitro biochemical tests, the clinical finding of graft tenderness, and combined [^99mTc]DTPA and [¹³¹I]orthoiodohippurate scintigraphy. With a sensitivity of 0.93 and a specificity of 0.95, IPS provided otherwise unavailable diagnostic information. Furthermore, postoperative IPS was a good predictor of long-term allograft survival.