HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rao, S. A. Articles by Isitman, A. T. Search for Related Content PubMed PubMed Citation Articles by Rao, S. A. Articles by Isitman, A. T.

Effect of Sn(II) Ion Concentration and Heparin on Technetium-99m Red Blood Cell Labeling

Nuclear Medicine Section, Medical College of Wisconsin, Milwaukee, Wisconsin

Correspondence: For reprints contact: Shyam A. Rao, PhD, Nuclear Medicine Section, Milwaukee County Medical Complex, 8700 W. Wisconsin Ave., Milwaukee, WI 53226.

ABSTRACT

While convenience and economy favor the use of in vivo methods for labeling red blood cells (RBCs) with [^99mTc]pertechnetate, previous reports suggested that patient medication such as heparin might interfere and thus result in inferior quality images. In this study, using a canine model, the role of stannous Sn(II) ion in in vivo and in vitro labeling of RBCs both in the presence and absence of a therapeutic dose of heparin was investigated. Our results showed that Sn(II) ion concentration of 20 µg/kg body weight levels provided better than 80% in vivo labeling efficiency enabling high quality blood-pool images even in the presence of therapeutic doses of heparin.

This article has been cited by other articles:

				A. Meyers, J. M. Durski, and A. A. Snow Nuclear Medicine Gastrointestinal Bleeding Examination Utilizing an UltraTag Kit Reveals Unusual Bone Marrow and Hepatic Uptake: A Case Study Report J. Nucl. Med. Technol., March 1, 2004; 32(1): 16 - 18. [Abstract] [Full Text] [PDF]