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Iodine-123-4-Amino-3-Iodobenzylguanidine, a New Sympathoadrenal Imaging Agent: Comparison with Iodine-123 Metaiodobenzylguanidine

Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: B. Shapiro, MB, ChB, PhD, Div. of Nuclear Medicine, Box 021, Dept. of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109.

ABSTRACT

Iodine-123-4-amino-3-iodobenzylguanidine ([¹²³I]AIBG), an analog of ¹²³I metaiodobenzylguanidine ([¹²³I]MIBG), has an advantage in having a more rapid and simple synthesis. This, combined with animal data that suggested a greater affinity of the new radiopharmaceutical for the autonomic innervation of the myocardium led us to study the biodistribution of [¹²³I]AIBG in three men with metastatic pheochromocytoma. In all instances, [¹²³I]AIBG revealed the same metastatic deposits shown by [¹²³I]MIBG. Iodine-123 AIBG uptake, however, was greater than [¹²³I]MIBG in lung, gut, and spleen. These higher backgrounds may pose diagnostic problems in some cases.

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