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The Journal of Nuclear Medicine Vol. 27 No. 6 829-833
© 1986 by Society of Nuclear Medicine
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Nuclear Magnetic Resonance and Gamma Camera Tumor Imaging Using Gadolinium-Labeled Monoclonal Antibodies

Wendie T. Anderson-Berg, Mette Strand , Todd E. Lempert, Arthur E. Rosenbaum and Peter M. Joseph

Department of Pharmacology and Experimental Therapeutics, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland; Pendergrass Diagnostic Radiology Research Lab, Hospital of the University of Pennyslvania, Philadelphia, Pennsylvania

Correspondence: For reprints contact: Mette Strand, PhD, Dept. of Pharmacology and Experimental Therapeutics Johns Hopkins University, School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205.

ABSTRACT

Chelate-derivatized monoclonal antibody labeled with the paramagnetic gadoiinium-3+ ion has been evaluated as a tumor-specific contrast-enhancing agent in nuclear magnetic resonance imaging in the Rauscher murine erythroleukemia system. With 10–7 M concentrations of Gd3+ delivered to the tumor target, a small but reproducible difference in proton relaxation times (T1s) was observed in excised tumors. Nuclear magnetic resonance imaging of animals, however, failed to show significant contrast enhancement of the tumor; by comparison, gamma camera images with 153Gd-labeled specific antibody did permit clear tumor visualization without subtraction. The potential use of monoclonal antibodies in tumor imaging appears to be far greater in gamma camera and positron imaging than in nuclear magnetic resonance imaging.






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Copyright © 1986 by the Society of Nuclear Medicine.