HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sharp, P. Articles by Smith, F. Search for Related Content PubMed PubMed Citation Articles by Sharp, P. Articles by Smith, F.

Application of Iodine-123-Labeled Isopropylamphetamine Imaging to the Study of Dementia

Departments of Biomedical Physics and Bioengineering, Mental Health, and Psychology, University of Aberdeen; and Clinical NMR Unit and Department of Nuclear Medicine, Aberdeen Royal Infirmary, Aberdeen, Scotland

Correspondence: For reprints contact: P. Sharp, PhD, Dept. of Biomedical Physics and Bioengineering, University of Aberdeen, Foresterhill, Aberdeen, AB9 2ZD, Scotland.

ABSTRACT

Forty-seven patients diagnosed as clinically demented were imaged with ¹²³I isopropylamphetamine (IMP). All of these patients also had a nuclear magnetic resonance (NMR) study. In those patients diagnosed as having senile dementia of the Alzheimer type a bilateral reduction in IMP uptake in the temporo-parieto-occipital region was always seen. The NMR appearances were normal in 64% of these sites. The IMP images of patients with multi-infarct dementia varied from normal to marked foca! deficits. There was, however, a much closer agreement between the abnormalities seen on the IMP and NMR images. In alcoholic dementia no focal areas of reduced IMP uptake were seen, although the uptake was generally irregular. In both Korsakoff's psychosis and Huntington's chorea the IMP uptake pattern and the NMR study were normal.

This article has been cited by other articles:

				Y. Akiyama, K. Moritake, T. Yamasaki, Y. Kimura, A. Kaneko, Y. Yamamoto, T. Miyazaki, and M. Daisu The Diagnostic Value of 123I-IMP SPECT in Non-Hodgkin's Lymphoma of the Central Nervous System J. Nucl. Med., November 1, 2000; 41(11): 1777 - 1783. [Abstract] [Full Text] [PDF]

				M. B. Imran, R. Kawashima, S. Awata, K. Sato, S. Kinomura, S. Ono, M. Sato, and H. Fukuda Tc-99m HMPAO SPECT in the evaluation of Alzheimer's disease: correlation between neuropsychiatric evaluation and CBF images J. Neurol. Neurosurg. Psychiatry, February 1, 1999; 66(2): 228 - 232. [Abstract] [Full Text]

				K. Kawabata, H. Tachibana, and M. Sugita Cerebral Blood Flow and Dementia in Parkinson's Disease J Geriatr Psychiatry Neurol, October 1, 1991; 4(4): 194 - 203. [Abstract] [PDF]