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Spurious Thyroid Cancer Metastasis: Saliva Contamination Artifact in High Dose Iodine-131 Metastases Survey

Division of Nuclear Medicine, Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana

Correspondence: For reprints contact: Hee-Myung Park, MD, Director, Division of Nuclear Medicine, Wishard Memorial Hospital, 1001 West Tenth St., Indianapolis, IN 46202.

ABSTRACT

The use of high dose ¹³¹I for workup of thyroid cancer patients increases the chance of contamination artifact which may mimic metastases. Two elderly male patients with follicular carcinoma of the thyroid had salivary contamination artifacts on metastatic survey scans. These patients received a 1 and 10 mCi dose of ¹³¹I, respectively. The artifacts were recognized only retrospectively when follow-up scans were obtained and compared. The characteristics of contamination artifacts and several methods to confirm these are discussed.

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