JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

The Journal of Nuclear Medicine Vol. 27 No. 4 560-562
© 1986 by Society of Nuclear Medicine
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Russell, C. D.
Right arrow Articles by Scott, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Russell, C. D.
Right arrow Articles by Scott, J. W.

Quality Control of Technetium-99m DTPA: Correlation of Analytic Tests with In Vivo Protein Binding in Man

Charles D. Russell, Katherine Rowell and Johnny W. Scott

Division of Nuclear Medicine
University of Alabama Hospitals
Nuclear Medicine Service, Birmingham V.A. Medical Center, Birmingham, Alabama

Correspondence: For reprints contact: Charles D. Russell, MD, Div. of Nuclear Medicine, University of Alabama Hospitals, 619-19th St. So., Birmingham, Al 35233.

ABSTRACT

When [99mTc]DTPA is administered, a small fraction of the activity (presumably an impurity) is bound to plasma proteins. This causes an error in the calculation of glomerular filtration rate from plasma clearance. This paper presents two methods of laboratory quality control for measuring the fraction that binds to plasma proteins. One method involves in vitro binding to human serum albumin followed by gel filtration. The other method involves descending paper chromatography on wet pre-equilibrated anion exchange paper. In a series of 80 patients, correlation was demonstrated between laboratory characteristics and actual clinical performance of the [99mTc]DTPA preparation. Both laboratory methods appear suitable for routine quality control.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
V. S. Lee, H. Rusinek, L. Bokacheva, A. J. Huang, N. Oesingmann, Q. Chen, M. Kaur, K. Prince, T. Song, E. L. Kramer, et al.
Renal function measurements from MR renography and a simplified multicompartmental model
Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1548 - F1559.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
C. D. Russell
A Bayesian 3-Compartment Model for 99mTc-MAG3 Clearance
J. Nucl. Med., August 1, 2003; 44(8): 1357 - 1361.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
V. S. Lee, H. Rusinek, M. E. Noz, P. Lee, M. Raghavan, and E. L. Kramer
Dynamic Three-dimensional MR Renography for the Measurement of Single Kidney Function: Initial Experience
Radiology, April 1, 2003; 227(1): 289 - 294.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
M. A. Serdar, I. Kurt, F. Ozcelik, M. Urhan, S. Ilgan, M. Yenicesu, L. Kenar, and T. Kutluay
A Practical Approach to Glomerular Filtration Rate Measurements: Creatinine Clearance Estimation Using Cimetidine
Ann. Clin. Lab. Sci., July 1, 2001; 31(3): 265 - 273.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
H. Arheden, M. Saeed, C. B. Higgins, D.-W. Gao, J. Bremerich, R. Wyttenbach, M. W. Dae, and M. F. Wendland
Measurement of the Distribution Volume of Gadopentetate Dimeglumine at Echo-planar MR Imaging to Quantify Myocardial Infarction: Comparison with 99mTc-DTPA Autoradiography in Rats
Radiology, June 1, 1999; 211(3): 698 - 708.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 1986 by the Society of Nuclear Medicine.