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A New Method for Granulocyte Labeling with Technetium-99m: Preliminary Results in Abscess Detection

National Institute of Radiation Hygiene, Østerås, Norway
Radiopharmaceutical Unit, Karolinska Pharmacy, Departments of Diagnostic Radiology, Hospital Physics, Surgery and Microbiology, Karolinska Hospital, Stockholm, Sweden
Institute for Energy Technology, Kjeller, Norway

Correspondence: For reprints contact: Erling Sundrehagen, MD, National Institute of Radiation Hygiene, Osterndalen 25, P.O. Box 55, N-1345 Ostreas, Norway.

ABSTRACT

A new method for ^99mTc-labeling of granulocytes for clinical routine use has been developed. The labeling is simple to perform by means of a kit of radiopharmaceutical quality, utilizing dihydroxy-benzoic acid. Pretinning techniques are avoided. The technique has been applied clinically in 15 patients with indications of intra-abdominal abscess. In six patients, [^99mTc]granulocyte scintigraphy at 3 hr and/or 24 hr after i.v. administration, correctly depicted the abscess, as verified by subsequent surgery. In the remaining patients, who were negative at surgery or recovered without operation, all scans were negative.