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Gallium-67 Uptake in the Lung of Asbestos Exposed Sheep: Early Association with Enhanced Macrophage-Derived Fibronectin Accumulation

Unité de recherche pulmonaire, Université de Sherbrooke, Sherbrooke, Québec, Canada

Correspondence: For reprints contact: R. Bégin, MD, CHUS, Sherbrooke, Québec, Canada, J1H 5N4.

ABSTRACT

To evaluate the time course and mechanisms of enhanced ⁶⁷Ga lung uptake in asbestosis, we exposed two groups of sheep every 2 wk to either 100 ml saline (controls) or 100 mg UICC chrysotile fibers in 100 ml saline. The sheep were evaluated periodically by pulmonary function tests (PFT), thoracic radiograph (TR), ⁶⁷Ga lung scan bronchoalveolar lavage (BAL), and transbronchial lung biopsy (TLB). By month 24 of the study, 9/15 exposed sheep had developed the initial alveolitis and had significant changes in PFT, TR, and TLB. The other six exposed sheep differed from controls only by a 75% increase in BAL fibronectin until month 30, where significant changes in albumin occurred and ⁶⁷Ga scan score increased. The nine sheep with alveolitis had significant sustained increases in ⁶⁷Ga scan and BAL levels from month 6, associated with a 150% increase in BAL fibronectin and other parameters of disease activity changed from month 18 to 30. We concluded that in the sheep model of asbestosis, significant changes in ⁶⁷Ga scan, ⁶⁷Ga BAL counts, and excessive elevation of BAL fibronectin preceded other parameters of disease activity. The data suggest that excessively activated macrophages are primarily responsible for the early ⁶⁷Ga lung uptake.

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