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Exercise Increases the Lung Clearance of Inhaled Technetium-99m DTPA

Départment de Médecine Nucléaire et de Biophysique, Centre Hospitalo-Universitaire Henri-Mondor, Creteil
Laboratoire de Physique et de Métrologie des aérosols, Institut de Protection et de Sûreté Nucléaore. Cen, Fontenay Aux Roses, France

Correspondence: For reprints contact: Michel Meignan, MD, Départment de Médecine Nucléaire et de Biophysique, Centre Hospitalo-Universitaire Heari-Mondor, 51, avenue du Maréchal de Lattre de Tassigny Creteil 94000, France.

ABSTRACT

The regional lung clearance of a deposited aerosol of [^99mTc] diethylenetriaminepentaacetic acid was successively computed at rest and at exercise in seven nonsmoking volunteers in upright posture. The subjects were seated on a bicycle with their backs against a gamma camera. At rest there was a gradient of clearance from the apex to the base of the lung, the apical clearance being significantly higher. At exercise this regional gradient was enhanced by a large and significant increase of the apical clearances (3.40 ± 0.63% min^–1 s.d. compared with 1.82 ± 0.75% min^–1 s.d. at rest, n = 7, p <0.01). By contrast the changes of the basal clearances were slight and unsignificant (1.46 ± 0.71% min^–1 s.d. compared with 1.40 ± 0.82% min^–1 s.d.). This increase of the apical lung clearance could be attributed primarily to the increase of apical blood flow induced by exercise and to the subsequent increase of the permeability surface area product.

FOOTNOTES

^* This work was presented at the 32nd Annual Meeting of The Society of Nuclear Medicine.

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