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Simplified Detection System for Neuroreceptor Studies in the Human Brain

Divisions of Nuclear Medicine and Radiation Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: For reprints contact: Alden N. Bice, PhD, Div. of Nuclear Medicine, 615 North Wolfe St., Rm. 2001, Baltimore, MD 21205-2179.

ABSTRACT

A simple, inexpensive dual-detector system has been developed for measurement of positron- emitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [¹¹C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates the potential utility of this system for estimating different degrees of receptor occupation in the human brain.