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Effect of Antibiotic Therapy on the Sensitivity of Indium-111-Labeled Leukocyte Scans

Division of Nuclear Medicine, Department of Radiology, University of Utah School of Medicine

Correspondence: For reprints contact: Frederick L. Datz, M.D., Clinical Director of Nuclear Medicine, University of Utah School of Medicine, 50 North Medical Dr., Salt Lake City, UT 84132.

ABSTRACT

Although ¹¹¹In-labeled leukocytes have been shown to be a useful technique for detecting infection, it has been postulated that antibiotic therapy may reduce the sensitivity of the leukocyte scan. Many patients with suspected bacterial infections are placed on antibiotics before a definite site of infection has been identified. Three hundred twelve leukocyte scans on 271 patients were retrospectively reviewed and classified as positive or negative, and as to whether or not they were being treated with antibiotics at the time the leukocyte scan was performed. The overall sensitivity, considering all 312 studies, was 90%. One hundred sixty-nine patient studies were on patients receiving antibiotics; 143 studies were on patients not on antibiotics. The sensitivity of the leukocyte scan was 88.7% in patients on antibiotic therapy; it was 92.1% in those who were not receiving antibiotics. The differences in sensitivity between the two groups were not significantly different (p < 0.05). We conclude that antibiotic therapy does not affect the sensitivity of the ¹¹¹In-labeled leukocyte scan.