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Pancreas Accumulation of Radioiodinated HIPDM in Mice and Rats

Medical Department, Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: A.B. Brill, MD, PhD, Medical Dept., Brookhaven National Laboratory, Upton, NY 11973.

ABSTRACT

High pancreatic affinity for ¹³¹I-labeled HIPDM was observed in mice and rats. Although the brain uptake of [¹³¹I]HIPDM is very fast, the pancreatic uptake is rather slow. The pancreas to liver ratios (per gram) were 5.08 ± 0.52 in mice and 5.15 ± 0.65 in rats at 2 hr and 7.05 ± 0.53 in mice and 8.06 ± 1.14 in rats at 5 hr after administration. These ratios are higher than those obtained with routinely used pancreatic agent [⁷⁵Se]selenomethionine. An increase in liver uptake and decrease in pancreatic uptake was observed at higher dose of carrier HIPDM, which resulted in lower pancreas to liver ratios. HIPDM is a new type of compound which shows predilection for pancreas. Our results that [¹²³I]HIPDM might be a useful agent for pancreas imaging.