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Delineation of a Transplanted Malignant Melanoma with Indium-111-Labeled Porphyrin

Center for Health Sciences, Lehigh University, Bethlehem, Pennsylvania
Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania
Royal Institute of Technology, Stockholm, Sweden

Correspondence: For reprints contact: Natalie Foster, PhD, Center for Health Sciences, Chandler-Ullmann Hall #17, Lehigh University, Bethlehem, PA 18015.

ABSTRACT

An indium complex of a cationic, water-soluble, synthetic porphyrin, tetra-4-N-methylpyridyl porphyrin tosylate, has been prepared and evaluated for its selective localization in tumors in Syrian Golden hamsters with flank transplanted malignant melanoma (Fortner MMI). Tumor-to-blood ratios of the compound increase from 42:1 at 6 hr postinjection, at which time activity levels in the tumor exceed those in all other tissues, to 162.1 at 72 hr. Images in one hamster at three time periods clearly delineated the tumor from nontarget background and also demarcated the viable and necrotic zones within the tumor itself.