HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Eckelman, W.C. Articles by Reba, R.C. Search for Related Content PubMed PubMed Citation Articles by Eckelman, W.C. Articles by Reba, R.C.

Use of 3-Quinuclidinyl 4-Iodobenzilate as a Receptor Binding Radiotracer

George Washington University Medical Center, Radiopharmaceutical Chemistry, Washington, DC
National Institutes of Health, Bethesda, Maryland
Armed Forces Radiobiology Research Institute, Bethesda, Maryland

Correspondence: For reprints contact: W.C. Eckelman, PhD, National Institutes of Health, Bethesda, MD 20205.

ABSTRACT

3-Quinuclidinyl 4-iodobenzilate was shown to bind to the muscarinic acetylcholine receptor (mAChR) by testing the saturability and the stereoselectivity in the corpus striatum, cerebellum, and the heart. But the ratio of radioactivity in tissues containing different concentrations of mAChR was less than the ratio of mAChR concentrations determined by in vitro saturation assay. As a result, the sensitivity to change in receptor concentration by external imaging will be reduced for this receptor binding radiotracer.