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Electrophoretic Analysis of Different Technetium-99m (SnCl₂) Methylene Diphosphonate Complexes

Division of Nuclear Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas

Correspondence: For reprints contact: A. Najafi, PhD, The University of Texas Medical Branch at Galveston, Div. of Nuclear Medicine, Galveston TX 77550.

ABSTRACT

Technetium-99m MDP was prepared from MDP kits from several different sources. The resulting [^99mTc]MDP preparations were analyzed by electrophoresis. The results demonstrated the presence of at least four different ^99mTc complexes in these preparations. Modified kit preparations were analyzed to show the effects of concentration and pH on formation of the impurities. The electrophoresis results were correlated with scintillation camera imaging studies in rabbits and suggest that hydrolysis of MDP to phosphate and methylphosphate results in formation of ^99mTc complexes with poor biological behavior as bone scanning agents.