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No Difference in Sensitivity for Occult Infection Between Tropolone- and Oxine-Labeled Indium-111 Leukocytes

Department of Radiology, University of Utah Medical Center; and Veterans Administration Medical Center, Salt Lake City, Utah

Correspondence: For reprints contact: Frederick L. Datz, MD, Dept. of Radiology, University of Utah School of Medicine, 50 North Medical Dr., Salt Lake City, UT 84109.

ABSTRACT

There is considerable disagreement as to whether oxine or tropolone is the best labeling agent for indium leukocytes. We have previously looked at the sensitivity of oxine-labeled ¹¹¹ln leukocyte scans for occult infections and now present a similar group of patients imaged with tropolone-labeled ¹¹¹ln leukocytes. Thirty-four patients (38 studies) with possible occult infection were prospectively studied. Patients were imaged 1–4 hr after injection and again at 24 hr postinjection. The early tropolone images had a sensitivity of 53% while the delayed images at 24 hr had a sensitivity of 93%. Based on a previous study, oxine-labeled leukocyte scans have an early sensitivity of 33% and a delayed sensitivity (at 24 hr) of 95%. The differences in sensitivity between oxine and tropolone when imaged early and at 24 hr were not statistically significant. We conclude that there is no significant difference in the ability to detect infection between oxine- and tropolone-labeled leukocytes, both early at 1–4 hr, and on delayed imaging 24 hr after injection.

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