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What Causes Uptake of Technetium-99m Methylene Diphosphonate by Tumors? A Case Where the Tumor Appeared to Secrete a Hypercalcemia-Causing Substance

Department of Internal Medicine, Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: James C. Sisson, MD, Div. of Nucl. Med., University of Michigan Medical Center, 1405 E. Ann St., Box 021, Ann Arbor, MI 48109.

ABSTRACT

A patient exhibited an unusual constellation of findings: His extraosseous lymphoma sequestered [^99mTc]MDP, a bone-seeking agent, while at the same time it appeared to produce a factor that caused hypercalcemia. The dispersed lymphoma cells took up more [^99mTc]MDP in vitro than did cultured lymphoblasts suggesting that the in vivo sequestration may have been, at least in part, an active intracellular process.