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In Vivo Effects of Iron-55 and Iron-59 on Mouse Testes: Biophysical Dosimetry of Auger Electrons

University of Medicine and Dentistry of New Jersey; Newark, New Jersey
University of Massachusetts; Amherst, Massachusetts

Correspondence: For reprints contact: Dandamudi V. Rao, PhD, Dept. of Radiology, University of Medicine and Dentistry of New Jersey, 100 Bergen St., Newark, NJ 07103.

ABSTRACT

When the Auger-electron emitter, ⁵⁵Fe, and the beta-emitter, ⁵⁹Fe, are similarly distributed in the testes of mice, the conventionally calculated average radiation dose to the organ from ⁵⁵Fe is about 2.6 times more effective in reducing the sperm-head count than the dose from ⁵⁹Fe. This finding emphasizes the ability of low-energy Auger electrons to damage radiosensitive targets of cells through localized irradiation. The observed efficacy is understandable in terms of dosimetric models based on intracellular distribution studies of the radionuclides.

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