HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by McPherson, D. W. Articles by Volkow, N. Search for Related Content PubMed PubMed Citation Articles by McPherson, D. W. Articles by Volkow, N.

Synthesis and Biodistribution of No-Carrier-Added [1-¹¹C]Putrescine

Department of Chemistry, Brookhaven National Laboratory, Upton, New York
Department of Psychiatry, New York University School of Medicine, New York, New York

Correspondence: For reprints contact: Dr. J. S. Fowler, Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973.

ABSTRACT

No-carrier-added [1-¹¹C]putrescine was synthesized in 20% radiochemical yield in a synthesis time of 50 min by the Michael addition of potassium [¹¹C]cyanide to acryionitrite followed by reduction of the [¹¹C]dinitrite with borane-methyl sulfide complex. Biodistribution in mice at 5, 30, and 60 min showed low uptake in normal brain tissue.

FOOTNOTES

^* Present address: Department of Psychiatry, The University of Texas Health Science Center, P.O. Box 20708, Houston, TX 77025.