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Lung Tumor Imaging by Positron Emission Tomography Using C-11 L-Methionine

The Research Institute for Tuberculosis and Cancer, and Cyclotron and Radio Isotope Center, Tohoku University, Sendai, Japan

Correspondence: For reprints contact: Kazuo Kubota, MD, Bldg. 490, Brookhaven National Laboratory, Upton, NY 11973.

ABSTRACT

This paper described the first clinical study of lung tumor scanning by positron emission tomography (PET) using C-11-labeled L-methionine (¹¹C-L-Met). Tumor images were clearly visualized by high contrast in eight lung cancer patients and also in a patient with a silicotic nodule. Quantitative evaluations of methionine uptake in tumor tissue and normal tissue by comparing differential uptake ratios suggested that the extent to which ¹¹C-L-Met accumulates in a tumor is closely correlated to the tumor's viability such as benign or malignant, viable or necrotic. ¹¹C-L-Met is considered to be an effective tumor marker for PET diagnosis which represents increased amino acid metabolism of tumors in the mediastinum and lung.

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