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Measurement of Splenic Function with Heat-Damaged RBCs: Effect of Heating Conditions: Concise Communication

Sydney Hospital, Sydney NSW 2000, Australia

Correspondence: For reprints contact: Peter E. Valk, MBBS, FRACP, Nuclear Medicine Dept. St Vincent's Hospital, Sydney NSW 2010, Australia.

ABSTRACT

RBCs labeled with Cr-51 were heated in saline, and RBCs labeled with Tc-99m were heated in plasma or as packed cells. Blood clearances were then compared. Clearance for saline-heated cells was faster than for heated, packed cells, and much faster than for plasma-heated cells. RBCs heated in plasma for 20 min at 49.5° were insufficiently damaged for measurement of spleen function, but adequate spleen images were obtained in all patients, despite half-clearance times that varied from 14 min to over 90 min.