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Performance Evaluation of SPRINT, A Single Photon Ring Tomography for Brain Imaging

University of Michigan, Ann Arbor, Michigan

Correspondence: For reprints contact: W. Leslie Rogers, PhD, University of Michigan Medical School, Cyclotron/PET Facility, 3480 Kresge I Box 056, Ann Arbor, MI 48109.

ABSTRACT

SPRINT, a prototype single photon tomograph, has been designed primarily for high-resolution brain imaging in humans with I-123-labeled compounds such as iodoamphetamine, hydroxyiodopropyldiamine (HIPDM), and iodobenzene (IBZ). SPRINT uses a ring of stationary, discrete Nal detectors, and fan-beam sampling is accomplished with a rotating eight-slit aperture ring that acquires a complete projection set in revolution. In-plane and cross-plane resolutions are 8mm and 10mm FWHM, respectively, measured on axis. Sensitivity with an 18% energy windows is 1000 cprs per µCi/cc for Tc-99m in a 20 cm diameter phantom. A detailed evaluation of system performance has been completed, and preliminary human brain blood flow images have been obtained using HIPDM.

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