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Patterns of Skeletal Scintigraphy and Their Relationship to Plasma and Urinary Histamine Levels in Systemic Mastocytosis

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

Correspondence: For reprints contact: Dean D. Metcalfe, MD, Building 10, Rm 11C-210, National Institutes of Health, Bethesda, MD 20205.

ABSTRACT

Scintigraphic findings in ten cases of systemic mastocytosis are described. Four radionuclide bone patterns were noted: normal, unifocal, multifocal, and diffuse. Compared with radiographic surveys, bone images were better able to show the widespread skeletal involvement in patients with diffuse disease, and to detect a greater number of focal lesions. Serum calcium, phosphorus, and hydroxyproline levels, were usually within normal limits even when the bone scintigrams were clearly abnormal. Plasma and urinary histamine levels were highest in patients whose bone images detected widespread skeletal involvement. In systemic mastocytosis, not only does scintigraphy document active bone disease more effectively than laboratory studies of bone metabolism and radiographs of bone, but it also appears to reflect the general severity of the disease process.

FOOTNOTES

^* Present address: Dept. of Diagnostic Radiology, University of Maryland Hospital, Baltimore, MD 21201.

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