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Sialadenitis following I-131 Therapy for Thyroid Carcinoma: Concise Communication

Cedars-Sinai Medical Center-UCLA School of Medicine, Los Angeles, California

Correspondence: For reprints contact: Glenn D. Braunstein, MD, Division of Endocrinology, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048.

ABSTRACT

During a 4-yr period, ten of 87 patients (11.5%) who received therapeutic doses of radioactive iodine (I-131) for thyroid carcinoma developed acute and/or chronic sialadenitis involving the parotid (five patients) or submandibular (four patients) glands, or both (one patients). Nine of the 10 patients had received prior I-131 therapy; the precipitating I-131 dose varied between 10 and 164 mCi. Onset of symptoms occurred between 1 day and 6 mo following therapy and the duration varied from 3 wk to 21/2 yr. This complication occurs more often than has been appreciated.

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