JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

The Journal of Nuclear Medicine Vol. 25 No. 6 706-713
© 1984 by Society of Nuclear Medicine
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rothendler, J. A.
Right arrow Articles by Pohost, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rothendler, J. A.
Right arrow Articles by Pohost, G. M.

Evaluation in Dogs of a New Double-Dose Technique for Imaging Changes in Myocardial Perfusion

James A. Rothendler*, Robert D. Okada, H. William Strauss, David A. Chesler and Gerald M. Pohost

Massachusetts General Hospital, Boston, Massachusetts

Correspondence: For reprints contact: James A. Rothendler, MD, Section of Cardiology, University Hospital, 75 East Newton St., Boston, MA 02118.

ABSTRACT

Assessment of myocardial perfusion with thallium immediately before and after an intervention that alters blood flow has been difficult due to presence of residual activity from the first tracer dose at the time of the second imaging. In a canine model we investigated a technique using two separate thallium injections during an intervention and after its reversal. Images were obtained after each injection, and a difference image was obtained by subtracting the first from the second image to correct for tracer persisting from the first injection. Intervention on coronary blood flow included: transient occlusion, subcritical stenosis with dipyridamole infusion, and permanent occlusion. The first images showed defects corresponding to the occlusion of stenosis, while the "difference" images correlated with myocardial perfusion at the time of the second injection. This technique allows rapid evaluation of changes in perfusion in response to interventions, and may find application in several clinical procedures.

FOOTNOTES

* Present address: Section of Cardiology, University Hospital, 75 East Newton St., Boston, MA 02118.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 1984 by the Society of Nuclear Medicine.